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Sensing it, they were to signal their partner, who squeezed the head of the penis between thumb and index finger, suppressing the ejaculatory reflex and allowing the man to last longer.

The squeeze technique worked, but many couples found it cumbersome.

Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual activity and with minimal penile stimulation.

Other researchers have noted that men who have premature ejaculation have a faster neurological response in the pelvic muscles. The physical process of ejaculation requires two actions: emission and expulsion. It involves deposition of fluid from the ampullary vas deferens, seminal vesicles, and prostate gland into the posterior urethra. It involves closure of bladder neck, followed by the rhythmic contractions of the urethra by pelvic-perineal and bulbospongiosus muscle, and intermittent relaxation of external urethral sphincters.Sympathetic motor neurons control the emission phase of ejaculation reflex, and expulsion phase is executed by somatic and autonomic motor neurons.Sex therapists estimate that the refined last-longer program teaches effective ejaculatory control to 90 percent of men.Drugs that increase serotonin signalling in the brain slow ejaculation and have been used successfully to treat PE.These include selective serotonin reuptake inhibitors (SSRIs), such as paroxetine or dapoxetine, as well as clomipramine.

Ejaculatory delay typically begins within a week of beginning medication.

Scientists have long suspected a genetic link to certain forms of premature ejaculation.

In one study, 91 percent of men who have had premature ejaculation for their entire lives also had a first-relative with lifelong premature ejaculation.

Other self-treatments include thrusting more slowly, withdrawing the penis altogether, purposefully ejaculating before sexual intercourse, and using more than one condom.

Using more than one condom is not recommended as the friction will often lead to breakage. By the 21st century, most men with premature ejaculation could cure themselves, either on their own or with a partner, using self-help resources, and only those with unusually severe problems had to consult sex therapists, who cured 75 to 80 percent.

and it included 2 other PE syndromes: "natural variable PE" and "premature-like ejaculatory dysfunction".